About Tigger transposable element-derived protein 6
Tigger transposable element-derived protein 6 (TIGD6) is a protein
from Homo sapiens identified by UniProt accession
Q17RP2, 521 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Tigger transposable element-derived protein 6 |
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| UniProt accession | Q17RP2 |
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| Gene | TIGD6 |
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| Organism | Homo sapiens |
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| Length | 521 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- total blood protein measurement · score 0.19
- aspartate aminotransferase measurement · score 0.19
- mean reticulocyte volume · score 0.18
- neutrophil percentage of leukocytes · score 0.16
- monocyte count · score 0.16
- monocyte percentage of leukocytes · score 0.15
- mean corpuscular volume · score 0.15
- heel bone mineral density · score 0.14
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RP2-F1 | alphafold | PREDICTED | 76.58 | — |
Amino-acid sequence (521 residues)
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K
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