About Collagen alpha-1(XXIV) chain
Collagen alpha-1(XXIV) chain (COL24A1) is a protein
from Homo sapiens identified by UniProt accession
Q17RW2, 1714 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Collagen alpha-1(XXIV) chain |
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| UniProt accession | Q17RW2 |
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| Gene | COL24A1 |
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| Organism | Homo sapiens |
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| Length | 1714 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (97)
Diseases linked to this target (Open Targets).
- Dupuytren Contracture · score 0.59
- diabetic foot · score 0.55
- Peyronie disease · score 0.55
- Skin ulcer · score 0.46
- burn · score 0.46
- Abnormality of connective tissue · score 0.46
- skin wound · score 0.46
- Edema · score 0.44
- decubitus ulcer · score 0.43
- intraocular pressure measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RW2-F1 | alphafold | PREDICTED | 48.88 | — |
Amino-acid sequence (1714 residues)
MHLRAHRTRR GKVSPTAKTK SLLHFIVLCV AGVVVHAQEQ GIDILHQLGL GGKDVRHSSP ATAVPSASTP LPQGVHLTES GVIFKNDAYI ETPFVKILPV NLGQPFTILT GLQSHRVNNA FLFSIRNKNR LQLGVQLLPK KLVVHIRGKQ PAVFNYSVHD EQWHSFAITI RNQSVSMFVE CGKKYFSTET IPEVQTFDSN SVFTLGSMNN NSIHFEGIVC QLDIIPSAEA SADYCRYVKQ QCRQADKYQP ETSIPCTTLI PTKIPEHSPP PKLFAEKVLS EDTFTEGKSI PNIIKNDSET VYKRQEHQIS RSQLSSLQSG NVSAVDLTNH GIQAKEMITE EDTQTNFSLS VTTHRISEAK MNTKEKFSSL LNMSDNITQH DDRVTGLSLF KKMPSILPQI KQDTITNLKK AITANLHTNE LMEMQPILNT SLHRVTNEPS VDNHLDLRKE GEFYPDATYP IENSYETELY DYYYYEDLNT MLEMEYLRGP KGDTGPPGPP GPAGIPGPSG KRGPRGIPGP HGNPGLPGLP GPKGPKGDPG FSPGQPVPGE KGDQGLSGLM GPPGMQGDKG LKGHPGLPGL PGEQGIPGFA GNIGSPGYPG RQGLAGPEGN PGPKGAQGFI GSPGEAGQLG PEGERGIPGI RGKKGFKGRQ GFPGDFGDRG PAGLDGSPGL VGGTGPPGFP GLRGSVGPVG PIGPAGIPGP MGLSGNKGLP GIKGDKGEQG TAGELGEPGY PGDKGAVGLP GPPGMRGKSG PSGQTGDPGL QGPSGPPGPE GFPGDIGIPG QNGPEGPKGL LGNRGPPGPP GLKGTQGEEG PIGAFGELGP RGKPGQKGYA GEPGPEGLKG EVGDQGNIGK IGETGPVGLP GEVGMTGSIG EKGERGSPGP LGPQGEKGVM GYPGPPGVPG PIGPLGLPGH VGARGPPGSQ GPKGQRGSRG PDGLLGEQGI QGAKGEKGDQ GKRGPHGLIG KTGNPGERGF QGKPGLQGLP GSTGDRGLPG EPGLRGLQGD VGPPGEMGME GPPGTEGESG LQGEPGAKGD VGTAGSVGGT GEPGLRGEPG APGEEGLQGK DGLKGVPGGR GLPGEDGEKG EMGLPGIIGP LGRSGQTGLP GPEGIVGIPG QRGRPGKKGD KGQIGPTGEV GSRGPPGKIG KSGPKGARGT RGAVGHLGLM GPDGEPGIPG YRGHQGQPGP SGLPGPKGEK GYPGEDSTVL GPPGPRGEPG PVGDQGERGE PGAEGYKGHV GVPGLRGATG QQGPPGEPGD QGEQGLKGER GSEGNKGKKG APGPSGKPGI PGLQGLLGPK GIQGYHGADG ISGNPGKIGP PGKQGLPGIR GGPGRTGLAG APGPPGVKGS SGLPGSPGIQ GPKGEQGLPG QPGIQGKRGH RGAQGDQGPC GDPGLKGQPG EYGVQGLTGF QGFPGPKGPE GDAGIVGISG PKGPIGHRGN TGPLGREGII GPTGRTGPRG EKGFRGETGP QGPRGQPGPP GPPGAPGPRK QMDINAAIQA LIESNTALQM ESYQNTEVTL IDHSEEIFKT LNYLSNLLHS IKNPLGTRDN PARICKDLLN CEQKVSDGKY WIDPNLGCPS DAIEVFCNFS AGGQTCLPPV SVTKLEFGVG KVQMNFLHLL SSEATHIITI HCLNTPRWTS TQTSGPGLPI GFKGWNGQIF KVNTLLEPKV LSDDCKIQDG SWHKATFLFH TQEPNQLPVI EVQKLPHLKT ERKYYIDSSS VCFL
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