About Cytoplasmic polyadenylation element-binding protein 4
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is a protein
from Homo sapiens identified by UniProt accession
Q17RY0, 729 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Cytoplasmic polyadenylation element-binding protein 4 |
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| UniProt accession | Q17RY0 |
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| Gene | CPEB4 |
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| Organism | Homo sapiens |
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| Length | 729 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (183)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.46
- neurodegenerative disease · score 0.45
- mean corpuscular volume · score 0.44
- Red cell distribution width · score 0.43
- reticulocyte count · score 0.42
- mean corpuscular hemoglobin · score 0.42
- systolic blood pressure · score 0.40
- Immature Reticulocyte Fraction Measurement · score 0.40
- BMI-adjusted waist-hip ratio · score 0.40
- mean corpuscular hemoglobin concentration · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RY0-F1 | alphafold | PREDICTED | 57.16 | — |
Amino-acid sequence (729 residues)
MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA ANGSSAGSAW LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKSEENQG DNSSENGNGK EKIRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS TIINEDASFF HQGGVPAASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ HHHSQHQQQR RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT IKGRLNYSYP GSDSSLLINA RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH SGLGSPHCFS HQNGERVERY SRKVFVGGLP PDIDEDEITA SFRRFGPLIV DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE IDKRVEVKPY VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA IHSRAGREFH KPLVKEGGDR PRHISFRWN
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