Protein Dok-7 (DOK7)

About Protein Dok-7

Protein Dok-7 (DOK7) is a protein from Homo sapiens identified by UniProt accession Q18PE1, 504 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Protein Dok-7
UniProt accession	Q18PE1
Gene	DOK7
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (121)

Diseases linked to this target (Open Targets).

Congenital myasthenic syndromes · score 0.81
Postsynaptic congenital myasthenic syndromes · score 0.72
fetal akinesia deformation sequence · score 0.69
fetal akinesia deformation sequence 1 · score 0.66
congenital myasthenic syndrome · score 0.63
genetic disorder · score 0.47
vital capacity · score 0.45
vitamin D measurement · score 0.44
Abnormality of the musculature · score 0.41
platelet count · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q18PE1-F1	alphafold	PREDICTED	64.31	—

Amino-acid sequence (504 residues)

MTEAALVEGQ VKLRDGKKWK SRWLVLRKPS PVADCLLMLV YKDKSERIKG LRERSSLTLE DICGLEPGLP YEGLVHTLAI VCLSQAIMLG FDSHEAMCAW DARIRYALGE VHRFHVTVAP GTKLESGPAT LHLCNDVLVL ARDIPPAVTG QWKLSDLRRY GAVPSGFIFE GGTRCGYWAG VFFLSSAEGE QISFLFDCIV RGISPTKGPF GLRPVLPDPS PPGPSTVEER VAQEALETLQ LEKRLSLLSH AGRPGSGGDD RSLSSSSSEA SHLDVSASSR LTAWPEQSSS SASTSQEGPR PAAAQAAGEA MVGASRPPPK PLRPRQLQEV GRQSSSDSGI ATGSHSSYSS SLSSYAGSSL DVWRATDELG SLLSLPAAGA PEPSLCTCLP GTVEYQVPTS LRAHYDTPRS LCLAPRDHSP PSQGSPGNSA ARDSGGQTSA GCPSGWLGTR RRGLVMEAPQ GSEATLPGPA PGEPWEAGGP HAGPPPAFFS ACPVCGGLKV NPPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards