Lysine-rich nucleolar protein 1 (KNOP1)

About Lysine-rich nucleolar protein 1

Lysine-rich nucleolar protein 1 (KNOP1) is a protein from Homo sapiens identified by UniProt accession Q1ED39, 458 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Lysine-rich nucleolar protein 1
UniProt accession	Q1ED39
Gene	KNOP1
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
waist circumference · score 0.09
hepatocellular carcinoma · score 0.08
late-onset Alzheimers disease · score 0.06
body mass index · score 0.06
platelet crit · score 0.04
platelet count · score 0.04
episodic ataxia type 1 · score 0.03
isolated dystonia · score 0.03
body height · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q1ED39-F1	alphafold	PREDICTED	53.41	—

Amino-acid sequence (458 residues)

MITKTHKVDL GLPEKKKKKK VVKEPETRYS VLNNDDYFAD VSPLRATSPS KSVAHGQAPE MPLVKKKKKK KKGVSTLCEE HVEPETTLPA RRTEKSPSLR KQVFGHLEFL SGEKKNKKSP LAMSHASGVK TSPDPRQGEE ETRVGKKLKK HKKEKKGAQD PTAFSVQDPW FCEAREARDV GDTCSVGKKD EEQAALGQKR KRKSPREHNG KVKKKKKIHQ EGDALPGHSK PSRSMESSPR KGSKKKPVKV EAPEYIPISD DPKASAKKKM KSKKKVEQPV IEEPALKRKK KKKRKESGVA GDPWKEETDT DLEVVLEKKG NMDEAHIDQV RRKALQEEID RESGKTEASE TRKWTGTQFG QWDTAGFENE DQKLKFLRLM GGFKNLSPSF SRPASTIARP NMALGKKAAD SLQQNLQRDY DRAMSWKYSR GAGLGFSTAP NKIFYIDRNA SKSVKLED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards