Dual oxidase maturation factor 2 (DUOXA2)

About Dual oxidase maturation factor 2

Dual oxidase maturation factor 2 (DUOXA2) is a protein from Homo sapiens identified by UniProt accession Q1HG44, 320 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Dual oxidase maturation factor 2
UniProt accession	Q1HG44
Gene	DUOXA2
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

familial thyroid dyshormonogenesis · score 0.64
congenital hypothyroidism · score 0.42
genetic disorder · score 0.41
transient congenital hypothyroidism · score 0.37
Red cell distribution width · score 0.09
serum iron measurement · score 0.09
transferrin saturation measurement · score 0.08
ulcerative colitis · score 0.07
total iron binding capacity · score 0.07
ferritin measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q1HG44-F1	alphafold	PREDICTED	83.06	—

Amino-acid sequence (320 residues)

MTLWNGVLPF YPQPRHAAGF SVPLLIVILV FLALAASFLL ILPGIRGHSR WFWLVRVLLS LFIGAEIVAV HFSAEWFVGT VNTNTSYKAF SAARVTARVR LLVGLEGINI TLTGTPVHQL NETIDYNEQF TWRLKENYAA EYANALEKGL PDPVLYLAEK FTPSSPCGLY HQYHLAGHYA SATLWVAFCF WLLSNVLLST PAPLYGGLAL LTTGAFALFG VFALASISSV PLCPLRLGSS ALTTQYGAAF WVTLATGVLC LFLGGAVVSL QYVRPSALRT LLDQSAKDCS QERGGSPLIL GDPLHKQAAL PDLKCITTNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards