About Protein inscuteable homolog
Protein inscuteable homolog (INSC) is a protein
from Homo sapiens identified by UniProt accession
Q1MX18, 579 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Protein inscuteable homolog |
|---|
| UniProt accession | Q1MX18 |
|---|
| Gene | INSC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 579 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (57)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.71
- bone quantitative ultrasound measurement · score 0.63
- vitamin D measurement · score 0.57
- bone density · score 0.39
- protein measurement · score 0.36
- information processing speed · score 0.34
- velocity of sound measurement · score 0.27
- acute graft vs. host disease · score 0.26
- hair color · score 0.15
- femoral neck bone mineral density · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q1MX18-F1 | alphafold | PREDICTED | 83.15 | — |
Amino-acid sequence (579 residues)
MRRPPGNGEA ASEGPGGWGL WGVQESRRLC CAGHDRCKQA LLQIGINMMA LPGGRHLDSV TLPGQRLHLM QVDSVQRWME DLKLMTECEC MCVLQAKPIS LEEDAQGDLI LAGGPGPGDP LQLLLKRGWV ISTELRRIGQ KLAQDRWARV HSMSVRLTCH ARSMVSEYSA VSRNSLKEMG EIEKLLMEKC SELSAVTERC LQVENEHVLK SMKACVSETL SMLGQHFGQL LELALTREVQ ALVRKIDASD NIYTTESTTG NLFSLTQEGA PLCRIIAKEG GVVALFKVCR QDSFRCLYPQ ALRTLASICC VEEGVHQLEK VDGVLCLADI LTDNSHSEAT RAEAAAVVAQ VTSPHLPVTQ HLSSFLESME EIVTALVKLC QEASSGEVFL LASAALANIT FFDTMACEML LQLNAIRVLL EACSDKQRVD TPYTRDQIVT ILANMSVLEQ CASDIIQENG VQLIMGMLSE KPRSGTPAEV AACERVQQKA AVTLARLSRD PDVAREAVRL SCMSRLIELC RSPSERNSSD AVLVACLAAL RRLAGVCPEG LQDSDFQQLV QPRLVDSFLL CSNMEESFV
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