MHC class I polypeptide-related sequence B (MICB)

About MHC class I polypeptide-related sequence B

MHC class I polypeptide-related sequence B (MICB) is a protein from Homo sapiens identified by UniProt accession Q29980, 383 residues long. MolForge cross-references it against 0 known binders and 240 disease associations.

Target properties

Protein name	MHC class I polypeptide-related sequence B
UniProt accession	Q29980
Gene	MICB
Organism	Homo sapiens
Length	383 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (240)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.39
rheumatoid arthritis · score 0.38
myositis · score 0.32
neurodegenerative disease · score 0.29
mean corpuscular hemoglobin · score 0.28
asthma · score 0.28
triglyceride measurement · score 0.27
MHC class I polypeptide-related sequence B measurement · score 0.27
type 2 diabetes mellitus · score 0.25
Dengue Hemorrhagic Fever · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q29980-F1	alphafold	PREDICTED	77.97	—

Amino-acid sequence (383 residues)

MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR DAAQLGFQPL MSATGSTGST EGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards