About C-type lectin domain family 12 member B
C-type lectin domain family 12 member B (CLEC12B) is a protein
from Homo sapiens identified by UniProt accession
Q2HXU8, 276 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | C-type lectin domain family 12 member B |
|---|
| UniProt accession | Q2HXU8 |
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| Gene | CLEC12B |
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| Organism | Homo sapiens |
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| Length | 276 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.17
- eosinophil count · score 0.05
- neutrophil count · score 0.03
- Vitiligo · score 0.03
- myeloid white cell count · score 0.02
- melanoma · score 0.02
- Crohn's disease · score 0.02
- tuberculosis · score 0.02
- cancer · score 0.01
- bacterial disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2HXU8-F1 | alphafold | PREDICTED | 86.88 | — |
Amino-acid sequence (276 residues)
MSEEVTYATL TFQDSAGARN NRDGNNLRKR GHPAPSPIWR HAALGLVTLC LMLLIGLVTL GMMFLQISND INSDSEKLSQ LQKTIQQQQD NLSQQLGNSN NLSMEEEFLK SQISSVLKRQ EQMAIKLCQE LIIHTSDHRC NPCPKMWQWY QNSCYYFTTN EEKTWANSRK DCIDKNSTLV KIDSLEEKDF LMSQPLLMFS FFWLGLSWDS SGRSWFWEDG SVPSPSLFST KELDQINGSK GCAYFQKGNI YISRCSAEIF WICEKTAAPV KTEDLD
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