About R-spondin-4
R-spondin-4 (RSPO4) is a protein
from Homo sapiens identified by UniProt accession
Q2I0M5, 234 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | R-spondin-4 |
|---|
| UniProt accession | Q2I0M5 |
|---|
| Gene | RSPO4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 234 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- Anonychia congenita totalis · score 0.71
- Congenital anonychia · score 0.68
- nonsyndromic congenital nail disorder 4 · score 0.68
- Anonychia · score 0.53
- genetic disorder · score 0.41
- blood protein measurement · score 0.34
- response to reverse transcriptase inhibitor · score 0.10
- HIV-1 infection · score 0.10
- peripheral neuropathy · score 0.10
- MODY · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2I0M5-F1 | alphafold | PREDICTED | 78.53 | — |
Amino-acid sequence (234 residues)
MRAPLCLLLL VAHAVDMLAL NRRKKQVGTG LGGNCTGCII CSEENGCSTC QQRLFLFIRR EGIRQYGKCL HDCPPGYFGI RGQEVNRCKK CGATCESCFS QDFCIRCKRQ FYLYKGKCLP TCPPGTLAHQ NTRECQGECE LGPWGGWSPC THNGKTCGSA WGLESRVREA GRAGHEEAAT CQVLSESRKC PIQRPCPGER SPGQKKGRKD RRPRKDRKLD RRLDVRPRQP GLQP
Explore R-spondin-4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets