DNA-binding protein RFX7 (RFX7)

About DNA-binding protein RFX7

DNA-binding protein RFX7 (RFX7) is a protein from Homo sapiens identified by UniProt accession Q2KHR2, 1460 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	DNA-binding protein RFX7
UniProt accession	Q2KHR2
Gene	RFX7
Organism	Homo sapiens
Length	1460 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities · score 0.67
neurodegenerative disease · score 0.56
Red cell distribution width · score 0.39
mean corpuscular volume · score 0.39
lysosomal storage disease · score 0.37
BMI-adjusted waist-hip ratio · score 0.36
mean corpuscular hemoglobin concentration · score 0.35
erythrocyte count · score 0.34
BMI-adjusted waist circumference · score 0.31
mean reticulocyte volume · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2KHR2-F1	alphafold	PREDICTED	43.07	—

Amino-acid sequence (1460 residues)

MAEEQQQPPP QQPDAHQQLP PSAPNSGVAL PALVPGLPGT EASALQHKIK NSICKTVQSK VDCILQEVEK FTDLEKLYLY LQLPSGLSNG EKSDQNAMSS SRAQQMHAFS WIRNTLEEHP ETSLPKQEVY DEYKSYCDNL GYHPLSAADF GKIMKNVFPN MKARRLGTRG KSKYCYSGLR KKAFVHMPTL PNLDFHKTGD GLEGAEPSGQ LQNIDEEVIS SACRLVCEWA QKVLSQPFDT VLELARFLVK SHYIGTKSMA ALTVMAAAPA GMKGITQPSA FIPTAESNSF QPQVKTLPSP IDAKQQLQRK IQKKQQEQKL QSPLPGESAA KKSESATSNG VTNLPNGNPS ILSPQPIGIV VAAVPSPIPV QRTRQLVTSP SPMSSSDGKV LPLNVQVVTQ HMQSVKQAPK TPQNVPASPG GDRSARHRYP QILPKPANTS ALTIRSPTTV LFTSSPIKTA VVPASHMSSL NVVKMTTISL TPSNSNTPLK HSASVSSATG TTEESRSVPQ IKNGSVVSLQ SPGSRSSSAG GTSAVEVKVE PETSSDEHPV QCQENSDEAK APQTPSALLG QKSNTDGALQ KPSNEGVIEI KATKVCDQRT KCKSRCNEML PGTSTGNNQS TITLSVASQN LTFTSSSSPP NGDSINKDPK LCTKSPRKRL SSTLQETQVP PVKKPIVEQL SAATIEGQKQ GSVKKDQKVP HSGKTEGSTA GAQIPSKVSV NVSSHIGANQ PLNSSALVIS DSALEQQTTP SSSPDIKVKL EGSVFLLDSD SKSVGSFNPN GWQQITKDSE FISASCEQQQ DISVMTIPEH SDINDLEKSV WELEGMPQDT YSQQLHSQIQ ESSLNQIQAH SSDQLPLQSE LKEFEPSVSQ TNESYFPFDD ELTQDSIVEE LVLMEQQMSM NNSHSYGNCL GMTLQSQSVT PGAPMSSHTS STHFYHPIHS NGTPIHTPTP TPTPTPTPTP TPTPTSEMIA GSQSLSRESP CSRLAQTTPV DSALGSSRHT PIGTPHSNCS SSVPPSPVEC RNPFAFTPIS SSMAYHDASI VSSSPVKPMQ RPMATHPDKT KLEWMNNGYS GVGNSSVSGH GILPSYQELV EDRFRKPHAF AVPGQSYQSQ SRHHDTHFGR LTPVSPVQHQ GATVNNTNKQ EGFAVPAPLD NKGTNSSASS NFRCRSVSPA VHRQRNLSGS TLYPVSNIPR SNVTPFGSPV TPEVHVFTNV HTDACANNIA QRSQSVPLTV MMQTAFPNAL QKQANSKKIT NVLLSKLDSD NDDAVRGLGM NNLPSNYTAR MNLTQILEPS TVFPSANPQN MIDSSTSVYE FQTPSYLTKS NSTGQINFSP GDNQAQSEIG EQQLDFNSTV KDLLSGDSLQ TNQQLVGQGA SDLTNTASDF SSDIRLSSEL SGSINDLNTL DPNLLFDPGR QQGQDDEATL EELKNDPLFQ QICSESMNSM TSSGFEWIES KDHPTVEMLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards