Germ cell-specific gene 1 protein (GSG1)

About Germ cell-specific gene 1 protein

Germ cell-specific gene 1 protein (GSG1) is a protein from Homo sapiens identified by UniProt accession Q2KHT4, 349 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Germ cell-specific gene 1 protein
UniProt accession	Q2KHT4
Gene	GSG1
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

serum albumin measurement · score 0.17
appendicular lean mass · score 0.13
bone quantitative ultrasound measurement · score 0.05
heel bone mineral density · score 0.05
body height · score 0.05
risk-taking behaviour · score 0.04
bone density · score 0.04
cholelithiasis · score 0.04
squamous cell carcinoma · score 0.03
urate measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2KHT4-F1	alphafold	PREDICTED	70.67	—

Amino-acid sequence (349 residues)

MAKMELSKAF SGQRTLLSAI LSMLSLSFST TSLLSNYWFV GTQKVPKPLC EKGLAAKCFD MPVSLDGDTN TSTQEVVQYN WETGDDRFSF RSFRSGMWLS CEETVEEPAL LHPQSWKQFR ALRSSGTAAA KGERCRSFIE LTPPAKREIL WLSLGTQITY IGLQFISFLL LLTDLLLTGN PACGLKLSAF AAVSSVLSGL LGMVAHMMYS QVFQATVNLG PEDWRPHVWN YGWAFYMAWL SFTCCMASAV TTFNTYTRMV LEFKCKHSKS FKENPNCLPH HHQCFPRRLS SAAPTVGPLT SYHQYHNQPI HSVSEGVDFY SELRNKGFQR GASQELKEAV RSSVEEEQC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards