About Serine protease 53
Serine protease 53 (PRSS53) is a protein
from Homo sapiens identified by UniProt accession
Q2L4Q9, 553 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Serine protease 53 |
|---|
| UniProt accession | Q2L4Q9 |
|---|
| Gene | PRSS53 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 553 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- hair shape measurement · score 0.25
- IGF-1 measurement · score 0.17
- mathematical ability · score 0.11
- feeling tense measurement · score 0.11
- psoriasis · score 0.10
- neuroticism measurement · score 0.10
- vital capacity · score 0.10
- insulin like growth factor measurement · score 0.09
- family history of Alzheimer’s disease · score 0.09
- Alzheimer disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2L4Q9-F1 | alphafold | PREDICTED | 85.45 | — |
Amino-acid sequence (553 residues)
MKWCWGPVLL IAGATVLMEG LQAAQRACGQ RGPGPPKPQE GNTVPGEWPW QASVRRQGAH ICSGSLVADT WVLTAAHCFE KAAATELNSW SVVLGSLQRE GLSPGAEEVG VAALQLPRAY NHYSQGSDLA LLQLAHPTTH TPLCLPQPAH RFPFGASCWA TGWDQDTSDA PGTLRNLRLR LISRPTCNCI YNQLHQRHLS NPARPGMLCG GPQPGVQGPC QGDSGGPVLC LEPDGHWVQA GIISFASSCA QEDAPVLLTN TAAHSSWLQA RVQGAAFLAQ SPETPEMSDE DSCVACGSLR TAGPQAGAPS PWPWEARLMH QGQLACGGAL VSEEAVLTAA HCFIGRQAPE EWSVGLGTRP EEWGLKQLIL HGAYTHPEGG YDMALLLLAQ PVTLGASLRP LCLPYPDHHL PDGERGWVLG RARPGAGISS LQTVPVTLLG PRACSRLHAA PGGDGSPILP GMVCTSAVGE LPSCEGLSGA PLVHEVRGTW FLAGLHSFGD ACQGPARPAV FTALPAYEDW VSSLDWQVYF AEEPEPEAEP GSCLANISQP TSC
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