About Coiled-coil domain-containing protein 27
Coiled-coil domain-containing protein 27 (CCDC27) is a protein
from Homo sapiens identified by UniProt accession
Q2M243, 656 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 27 |
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| UniProt accession | Q2M243 |
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| Gene | CCDC27 |
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| Organism | Homo sapiens |
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| Length | 656 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.18
- hemoglobin measurement · score 0.18
- erythrocyte count · score 0.12
- mean corpuscular hemoglobin concentration · score 0.11
- acute myeloid leukemia · score 0.10
- mean corpuscular volume · score 0.10
- PHF-tau measurement · score 0.08
- serum copper measurement · score 0.08
- hemoglobin A1 measurement · score 0.08
- HbA1c measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2M243-F1 | alphafold | PREDICTED | 65.66 | — |
Amino-acid sequence (656 residues)
MFEAIFPSTP QARLKRDPRE KPGLSSFRST FRQQSSLGLC IPRLMLPKEA SPSQRHSSMS SSMARALVLL QSMASRDARC PEWKPHQKPR TLSKSVQTIS RYYRKTSEPK DAASLTGFMS KMELRRVFPT HPDCPQFSTR ATSMSHCGSP TEADLSGEID NSSETWRGTQ DLFLARRGSD TNVDGYLLPF SKSICEFDYL RKRRKSQTLS PVTSSSVASQ SCLRKRMPWY LSVIHEKDHC LSELEIQVQK KDEEILLLQE EREALKMQLK CLLKGKGQET SMSPGRREQL SDASLKLGRL SLLKAFSRHE EELQHWWQMQ EESAAPERGK EPDLGGGEED EGLEGEPDGV EDTGAWGGVS QMGSVHEEGS EEEEEEEGDR DEDSEERELP EEEEIPRRRA SSLAESFEEE LLAQLEEYEQ VILDFQFNLE ATRTRYSLAT GVIASLQQQV DFQETQLRKI NTENETLQKE LRERRQQLQA MTDKFSNLRE DKKHQEMMGL IEKDNQLLRQ QVSELERKLT KRDCVISELD TKVSQLQEQV ELDQNHLQRW KQLQEDLQSK KEMIQQAEQH TRVALESSQS RLERLRNKII QATFSISGTK SLANEISDND ILEALQRIIS ERSDYYNQLK QKGVKVPPLQ QSEAFLTSKS KKGTSK
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