About Methenyltetrahydrofolate synthase domain-containing protein
Methenyltetrahydrofolate synthase domain-containing protein (MTHFSD) is a protein
from Homo sapiens identified by UniProt accession
Q2M296, 383 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Methenyltetrahydrofolate synthase domain-containing protein |
|---|
| UniProt accession | Q2M296 |
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| Gene | MTHFSD |
|---|
| Organism | Homo sapiens |
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| Length | 383 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.38
- body height · score 0.30
- heel bone mineral density · score 0.28
- bone density · score 0.27
- diastolic blood pressure · score 0.26
- bone quantitative ultrasound measurement · score 0.25
- cortical surface area measurement · score 0.25
- colorectal cancer · score 0.23
- dentures · score 0.23
- femoral neck bone mineral density · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2M296-F1 | alphafold | PREDICTED | 84.68 | — |
Amino-acid sequence (383 residues)
MEPRAVGVSK QDIREQIWGY MESQNLADFP RPVHHRIPNF KGSYLACQNI KDLDVFARTQ EVKVDPDKPL EGVRLLVLQS KKTLLVPTPR LRTGLFNKIT PPPGATKDIL RKCATSQGVR NYSVPIGLDS RVLVDLVVVG SVAVSEKGWR IGKGEGYADL EYAMMVSMGA VSKETPVVTI VHDCQVVDIP EELVEEHDIT VDYILTPTRV IATGCKRPKP MGITWFKISL EMMEKIPILR SLRAREQQAG KDVTLQGEHQ HLPEPGCQQT VPLSVGRRPP DTPGPETNSM EAAPGSPPGE GAPLAADVYV GNLPGDARVS DLKRALRELG SVPLRLTWQG PRRRAFLHYP DSAAAQQAVS CLQGLRLGTD TLRVALARQQ RDK
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