Outer dense fiber protein 4 (ODF4)

About Outer dense fiber protein 4

Outer dense fiber protein 4 (ODF4) is a protein from Homo sapiens identified by UniProt accession Q2M2E3, 257 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Outer dense fiber protein 4
UniProt accession	Q2M2E3
Gene	ODF4
Organism	Homo sapiens
Length	257 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.29
apolipoprotein A 1 measurement · score 0.16
erythrocyte count · score 0.11
high density lipoprotein cholesterol measurement · score 0.10
azoospermia · score 0.10
total cholesterol measurement · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
hematocrit · score 0.08
red blood cell density measurement · score 0.08
partial chromosome Y deletion · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2M2E3-F1	alphafold	PREDICTED	55.22	—

Amino-acid sequence (257 residues)

MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL SLSSNRSLGQ RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF SKKWLDLSRS LFYQRWPVDV SNRIHTSAHV MSMGLLHFYK SRSCSDLENG KVTFIFSTLM LFPINIWIFE LERNVSIPIG WSYFIGWLVL ILYFTCAILC YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT PITQEGVLDP EQKDTHV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards