Protein FAM83E (FAM83E)

About Protein FAM83E

Protein FAM83E (FAM83E) is a protein from Homo sapiens identified by UniProt accession Q2M2I3, 478 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Protein FAM83E
UniProt accession	Q2M2I3
Gene	FAM83E
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

sphingomyelin measurement · score 0.32
alkaline phosphatase measurement · score 0.28
neutrophil count · score 0.28
lymphocyte count · score 0.26
leukocyte count · score 0.24
myeloid white cell count · score 0.22
Red cell distribution width · score 0.22
neutrophil-to-lymphocyte ratio · score 0.21
lymphocyte percentage of leukocytes · score 0.17
neutrophil percentage of leukocytes · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2M2I3-F1	alphafold	PREDICTED	69.56	—

Amino-acid sequence (478 residues)

MAASQLAALE GVDSGPRVPG ASPGFLYSEG QRLALEALLS KGAEAFQTCV QREELWPFLS ADEVQGLAAA AEDWTVAKQE PSGMAEGATT TDVDAGSLSY WPGQSEQPAP VLRLGWPVDS AWKGITRAQL YTQPPGEGQP PLKELVRLEI QAAHKLVAVV MDVFTDPDLL LDLVDAATRR WVPVYLLLDR QQLPAFLELA QQLGVNPWNT ENVDVRVVRG CSFQSRWRRQ VSGTVREKFV LLDGERVISG SYSFTWSDAR LHRGLVTLLT GEIVDAFSLE FRTLYAASCP LPPAPPQKPS VIGGLQRGRS PHRVSRRRSV APASPPPPDG PLAHRLAACR VSPATPGPAL SDILRSVQRA RTPSGPPARP SRSMWDLSRL SQLSGSSDGD NELKKSWGSK DTPAKALMRQ RGTGGGPWGE VDSRPPWGGA LPLPPAHRLR YLSPARRRFG GDATFKLQEP RGVRPSDWAP RAGLGGQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards