About Cilia- and flagella-associated protein 184
Cilia- and flagella-associated protein 184 (CFAP184) is a protein
from Homo sapiens identified by UniProt accession
Q2M329, 555 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 184 |
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| UniProt accession | Q2M329 |
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| Gene | CFAP184 |
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| Organism | Homo sapiens |
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| Length | 555 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.46
- platelet count · score 0.43
- mosaic loss of chromosome Y measurement · score 0.37
- monocyte percentage of leukocytes · score 0.34
- mean corpuscular volume · score 0.31
- mean platelet volume · score 0.31
- lymphocyte:monocyte ratio · score 0.29
- granulocyte count · score 0.25
- sum of neutrophil and eosinophil counts · score 0.25
- neutrophil count · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2M329-F1 | alphafold | PREDICTED | 67.76 | — |
Amino-acid sequence (555 residues)
MDVSSEHTKD PGGEGGDGES LAARPSKIKA SSGPPTSPEP GELESEPEEE EEEQAASQGG TAADEQAEAP KGLTAAEAAG EEGPGEPGRP AEPQPEPEEP AEVGAEEPAQ PEPGAGPEEL EAEAGAEELE QAAEGKEVRF QASLPLTRID EEEAAAAPEA ETERVEGEEE DKEETQRDGA ESKERDGEGR PAKSQEEGKR LYGRDEFEDL EWSEEVQKLQ EQQLRSDLLD QYRSLLVERN RSQRYNLYLQ HKIFEALRRK KGLEAAEVAD RGAEAEAPEK EQAYLRHLGM LEELKKQQAD DLQWYHQELG QLKRQCQEKL TRVEKEWRRF QALKKQVVMQ AMGSCRMRGG RQAALREVEQ IQALEDKKEK EMSAVRLENI QLKQSLVHFE TRMRTQEDLT QGLLLIDFEQ LKIENQTFNE KIEERNEELL KLRSKVTNSV QVITHVKEKL HFMDMENACK KTQLAEIEAQ AALGRDILTK TKQAREGLRT DNIRLNQKCG LLGKDSLLRD LEEKVDKTEL LHRRLESLKR HHASLTLSCR GVRQKIREAK AFLPS
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