About Sodium/glucose cotransporter 4
Sodium/glucose cotransporter 4 (SLC5A9) is a protein
from Homo sapiens identified by UniProt accession
Q2M3M2, 681 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Sodium/glucose cotransporter 4 |
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| UniProt accession | Q2M3M2 |
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| Gene | SLC5A9 |
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| Organism | Homo sapiens |
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| Length | 681 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (35)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.39
- uric acid measurement · score 0.28
- calcium measurement · score 0.10
- meralgia paresthetica · score 0.09
- balding measurement · score 0.06
- heel bone mineral density · score 0.06
- urinary metabolite measurement · score 0.05
- Crohn's disease · score 0.04
- PHF-tau measurement · score 0.04
- Barrett's esophagus · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2M3M2-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (681 residues)
MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH VCNINAVLLL AINIFLWGYF A
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