Zinc finger protein 674 (ZNF674)

About Zinc finger protein 674

Zinc finger protein 674 (ZNF674) is a protein from Homo sapiens identified by UniProt accession Q2M3X9, 581 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Zinc finger protein 674
UniProt accession	Q2M3X9
Gene	ZNF674
Organism	Homo sapiens
Length	581 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

non-syndromic X-linked intellectual disability · score 0.12
non-small cell lung carcinoma · score 0.09
hepatocellular carcinoma · score 0.08
gonorrhea · score 0.05
mental or behavioural disorder · score 0.05
neuroblastoma · score 0.04
neoplasm · score 0.03
cancer · score 0.02
Treacher-Collins syndrome · score 0.01
Sepsis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2M3X9-F1	alphafold	PREDICTED	65.80	—

Amino-acid sequence (581 residues)

MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGHL VGKPDVIFRL GPGDESWMAD GGTPVRTCAG EDRPEVWEVD EQIDHYKESQ DKFLWQAAFI GKETLKDESG QECKICRKII YLNTDFVSVK QRLPKYYSWE RCSKHHLNFL GQNRSYVRKK DDGCKAYWKV CLHYNLHKAQ PAERFFDPNQ RGKALHQKQA LRKSQRSQTG EKLYKCTECG KVFIQKANLV VHQRTHTGEK PYECCECAKA FSQKSTLIAH QRTHTGEKPY ECSECGKTFI QKSTLIKHQR THTGEKPFVC DKCPKAFKSS YHLIRHEKTH IRQAFYKGIK CTTSSLIYQR IHTSEKPQCS EHGKASDEKP SPTKHWRTHT KENIYECSKC GKSFRGKSHL SVHQRIHTGE KPYECSICGK TFSGKSHLSV HHRTHTGEKP YECRRCGKAF GEKSTLIVHQ RMHTGEKPYK CNECGKAFSE KSPLIKHQRI HTGERPYECT DCKKAFSRKS TLIKHQRIHT GEKPYKCSEC GKAFSVKSTL IVHHRTHTGE KPYECRDCGK AFSGKSTLIK HQRSHTGDKN L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards