Regulator of G-protein signaling 21 (RGS21)

About Regulator of G-protein signaling 21

Regulator of G-protein signaling 21 (RGS21) is a protein from Homo sapiens identified by UniProt accession Q2M5E4, 152 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Regulator of G-protein signaling 21
UniProt accession	Q2M5E4
Gene	RGS21
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.23
glioblastoma multiforme · score 0.22
thyroid gland adenocarcinoma · score 0.22
respiratory failure · score 0.17
ovarian cancer · score 0.09
pancreatic adenocarcinoma · score 0.04
celiac disease · score 0.01
diffuse large B-cell lymphoma · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2M5E4-F1	alphafold	PREDICTED	85.32	—

Amino-acid sequence (152 residues)

MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP FL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards