R-spondin-1 (RSPO1)

About R-spondin-1

R-spondin-1 (RSPO1) is a protein from Homo sapiens identified by UniProt accession Q2MKA7, 263 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	R-spondin-1
UniProt accession	Q2MKA7
Gene	RSPO1
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (199)

Diseases linked to this target (Open Targets).

palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome · score 0.73
Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma · score 0.66
Palmoplantar keratoderma · score 0.46
refractive error measurement · score 0.43
corneal topography · score 0.39
intraocular pressure measurement · score 0.28
axial length measurement · score 0.27
genetic disorder · score 0.19
balding measurement · score 0.16
ovarian carcinoma · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2MKA7-F1	alphafold	PREDICTED	74.70	—

Amino-acid sequence (263 residues)

MRLGLCVVAL VLSWTHLTIS SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards