About Protein mono-ADP-ribosyltransferase PARP6
Protein mono-ADP-ribosyltransferase PARP6 (PARP6) is a protein
from Homo sapiens identified by UniProt accession
Q2NL67, 630 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP6 |
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| UniProt accession | Q2NL67 |
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| Gene | PARP6 |
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| Organism | Homo sapiens |
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| Length | 630 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (52)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- microcephaly · score 0.23
- Intellectual disability · score 0.23
- Microcephaly · score 0.23
- epilepsy · score 0.23
- urate measurement · score 0.21
- brain measurement · score 0.18
- hematocrit · score 0.13
- erythrocyte count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2NL67-F1 | alphafold | PREDICTED | 73.56 | — |
Amino-acid sequence (630 residues)
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED GQVGDANINT QDPKIQKEIM RVIGTQVYTN
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