Proline and serine-rich protein 3 (PROSER3)

About Proline and serine-rich protein 3

Proline and serine-rich protein 3 (PROSER3) is a protein from Homo sapiens identified by UniProt accession Q2NL68, 480 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Proline and serine-rich protein 3
UniProt accession	Q2NL68
Gene	PROSER3
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

body height · score 0.20
white matter microstructure measurement · score 0.16
blood protein measurement · score 0.13
age at first sexual intercourse measurement · score 0.11
mathematical ability · score 0.06
cortical thickness · score 0.06
Red cell distribution width · score 0.06
self reported educational attainment · score 0.05
age at menarche · score 0.05
cortical surface area measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2NL68-F1	alphafold	PREDICTED	57.01	—

Amino-acid sequence (480 residues)

MDRSLPVFSI QDSPFGDAPL GRSHYWPSQS QTWCPKTLSP SRSQRSRLPQ APKALATGPN SPELFEESWP SSSGTPSLPS TTEGQMWASP APTLIDSGDS VVAKYINRFR QAQPTSREER QPAGPTPADF WWLQSDSPDP SSQSAAAGAN KPEGRPHTAV PTAVNVTSAS HAVAPLQEIK QNLHTWNSSL LDLETLSLQS RAARLLKRSK ASISSSSSLS PSDASTSSFP TSSDGLSPFS ETFIPDSSKG LGPRAPASPA PAQAQTPTPA PAPASSQAPL RPEDDILYQW RQRRKLEQAQ GSKGDRAWVP PLTPALRTLA ESLKAKALPP AAGSVIRKSE ATPSPGACLQ PEVPLSPAEQ ATTVKASPPA FQVGSPEALA PPPPAADHAP SEALLAQAAL LLQAAEDSDG SEFQDDPVLQ VLRAHRAELS RQKREADARL SFLLDQAEDL GSWSPPAGSP PRSPRRLLRR EGDSLEARRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards