About Protein C-mannosyl-transferase DPY19L1
Protein C-mannosyl-transferase DPY19L1 (DPY19L1) is a protein
from Homo sapiens identified by UniProt accession
Q2PZI1, 675 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Protein C-mannosyl-transferase DPY19L1 |
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| UniProt accession | Q2PZI1 |
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| Gene | DPY19L1 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (91)
Diseases linked to this target (Open Targets).
- physical activity measurement · score 0.32
- diet measurement · score 0.32
- diastolic blood pressure · score 0.28
- exercise · score 0.23
- PHF-tau measurement · score 0.13
- body height · score 0.10
- metabolite measurement · score 0.10
- azoospermia · score 0.06
- partial chromosome Y deletion · score 0.05
- carotid artery intima media thickness · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2PZI1-F1 | alphafold | PREDICTED | 88.47 | — |
Amino-acid sequence (675 residues)
MEGRPPPEGR PPPRPRTGRA PRGRRRAVFA AVLHWSHITH LFENDRHFSH LSTLEREMAF RTEMGLYYSY FKTIVEAPSF LNGVWMIMND KLTEYPLVIN TLKRFNLYPE VILASWYRIY TKIMDLIGIQ TKICWTVTRG EGLSPIESCE GLGDPACFYV AVIFILNGLM MALFFIYGTY LSGSRLGGLV TVLCFFFNHG ECTRVMWTPP LRESFSYPFL VLQMLLVTHI LRATKLYRGS LIALCISNVF FMLPWQFAQF VLLTQIASLF AVYVVGYIDI CKLRKIIYIH MISLALCFVL MFGNSMLLTS YYASSLVIIW GILAMKPHFL KINVSELSLW VIQGCFWLFG TVILKYLTSK IFGIADDAHI GNLLTSKFFS YKDFDTLLYT CAAEFDFMEK ETPLRYTKTL LLPVVLVVFV AIVRKIISDM WGVLAKQQTH VRKHQFDHGE LVYHALQLLA YTALGILIMR LKLFLTPHMC VMASLICSRQ LFGWLFCKVH PGAIVFAILA AMSIQGSANL QTQWNIVGEF SNLPQEELIE WIKYSTKPDA VFAGAMPTMA SVKLSALRPI VNHPHYEDAG LRARTKIVYS MYSRKAAEEV KRELIKLKVN YYILEESWCV RRSKPGCSMP EIWDVEDPAN AGKTPLCNLL VKDSKPHFTT VFQNSVYKVL EVVKE
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