Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)

About Isoamyl acetate-hydrolyzing esterase 1 homolog

Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) is a protein from Homo sapiens identified by UniProt accession Q2TAA2, 248 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Isoamyl acetate-hydrolyzing esterase 1 homolog
UniProt accession	Q2TAA2
Gene	IAH1
Organism	Homo sapiens
Length	248 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

neonatal inflammatory skin and bowel disease · score 0.49
body height · score 0.23
birth weight · score 0.19
genetic disorder · score 0.18
waist-hip ratio · score 0.17
tumor necrosis factor receptor 1 measurement · score 0.12
parental genotype effect measurement · score 0.09
appendicular lean mass · score 0.08
mean platelet volume · score 0.07
Romano-Ward syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2TAA2-F1	alphafold	PREDICTED	93.09	—

Amino-acid sequence (248 residues)

MALCEAAGCG SALLWPRLLL FGDSITQFSF QQGGWGASLA DRLVRKCDVL NRGFSGYNTR WAKIILPRLI RKGNSLDIPV AVTIFFGAND SALKDENPKQ HIPLEEYAAN LKSMVQYLKS VDIPENRVIL ITPTPLCETA WEEQCIIQGC KLNRLNSVVG EYANACLQVA QDCGTDVLDL WTLMQDSQDF SSYLSDGLHL SPKGNEFLFS HLWPLIEKKV SSLPLLLPYW RDVAEAKPEL SLLGDGDH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards