About Coiled-coil domain-containing protein 57
Coiled-coil domain-containing protein 57 (CCDC57) is a protein
from Homo sapiens identified by UniProt accession
Q2TAC2, 915 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 57 |
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| UniProt accession | Q2TAC2 |
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| Gene | CCDC57 |
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| Organism | Homo sapiens |
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| Length | 915 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- serum urea measurement · score 0.27
- blood urea nitrogen measurement · score 0.23
- neurodegenerative disease · score 0.21
- body mass index · score 0.20
- blood metabolite measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.15
- body height · score 0.13
- Blackfan-Diamond anemia · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAC2-F1 | alphafold | PREDICTED | 70.18 | — |
Amino-acid sequence (915 residues)
MLPLGSEPAL NELLLRKEEE WRALQAHRTQ LQEAALQDTR SQLEEAQGKL RCLQEDFVYN LQVLEERDLE LERYDAAFAQ AREWEEARRA EVSELKIEAA KLRQALAREA RKVEELQQQQ QLAFQEHRLE LERVHSDKNG EIDHHREQYE NLKWTLERKL EELDGELALQ RQELLLEFES KMRKREHEFR LQADNMSNTA LSRELKVKLL HKELEALKEA GAKAAESLQR AEATNAELER KLQSRAGELQ DLEAMSRARV KDLEDKLHSV QLTRKKEEET FKRKHEELDR LAREKDAVLV AVKGAHVEQL QELQTRVLEL QAHCETLEAQ LRRAEWRQAD TAKEKDAAID QLREDASTVK SAWDAQIAQL SKEMVSRDLQ IQTLQEEEVK LKAQVARSQQ DIERYKQQLS LAVERERSLE RDQVQLGLDW QRRCDDIERD QIQKSEALIQ GLSMAKSQVA AKLQETEQAL QEQEVVLKAV TLERDQAVQA LRMHGLPRPG AQMLLRQHEE EISKDFPSSE IQRLREQNTS LRNAIAQMRK EMEALSHQIP PPIQTAAEST DANQPDPEAG GDAATPDYVL ALEAEIRTLK HKFKTLEKHL EDVLDPLKMS SPHAESQPSV RTSTETTGGS AQAGQAGGSV QAGQAGGSVQ AGPVSSGLAL RKLGDRVQLL NLLVTRLRQK VLREPLEPAA LQRELPREVD QVHLEVLELR KQVAELGKHL RIAQHGGAEP SGRKQPPASD AVALGREDAK SAEDEAPSRH LGKHQPRSAQ VGSRLDALQG PKTQHSIHTV TCKSPRQKED RSPKPPQAPQ HPEEHGRQSH SSSSFASGTL QDMWRLLDLG SSPSGVTSQG DSTPELPAPP AADRRPVKMQ AGIATPGMKT AAQAKAKTTG ASRSHPAKAK GCQRPPKIRN YNIMD
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