About Kinesin-like protein KIF19
Kinesin-like protein KIF19 (KIF19) is a protein
from Homo sapiens identified by UniProt accession
Q2TAC6, 998 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Kinesin-like protein KIF19 |
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| UniProt accession | Q2TAC6 |
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| Gene | KIF19 |
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| Organism | Homo sapiens |
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| Length | 998 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- Non-immune hydrops fetalis · score 0.42
- low grade glioma · score 0.18
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.15
- glioblastoma multiforme · score 0.15
- PHF-tau measurement · score 0.07
- DNA methylation · score 0.05
- 46,XY complete gonadal dysgenesis · score 0.04
- ring chromosome Y · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAC6-F1 | alphafold | PREDICTED | 64.61 | — |
Amino-acid sequence (998 residues)
MKDSGDSKDQ QLMVALRVRP ISVAELEEGA TLIAHKVDEQ MVVLMDPMED PDDILRAHRS REKSYLFDVA FDFTATQEMV YQATTKSLIE GVISGYNATV FAYGPTGCGK TYTMLGTDQE PGIYVQTLND LFRAIEETSN DMEYEVSMSY LEIYNEMIRD LLNPSLGYLE LREDSKGVIQ VAGITEVSTI NAKEIMQLLM KGNRQRTQEP TAANQTSSRS HAVLQVTVRQ RSRVKNILQE VRQGRLFMID LAGSERASQT QNRGQRMKEG AHINRSLLAL GNCINALSDK GSNKYINYRD SKLTRLLKDS LGGNSRTVMI AHISPASSAF EESRNTLTYA GRAKNIKTRV KQNLLNVSYH IAQYTSIIAD LRGEIQRLKR KIDEQTGRGQ ARGRQDRGDI RHIQAEVQLH SGQGEKAGMG QLREQLASAF QEQMDVRRRL LELENRAMEV QIDTSRHLLT IAGWKHEKSR RALKWREEQR KECYAKDDSE KDSDTGDDQP DILEPPEVAA ARESIAALVD EQKQLRKQKL ALEQRCRELR ARGRRLEETL PRRIGSEEQR EVLSLLCRVH ELEVENTEMQ SHALLRDGAL RHRHEAVRRL EQHRSLCDEI IQGQRQIIDD YNLAVPQRLE ELYEVYLREL EEGSLEQATI MDQVASRALQ DSSLPKITPA GTSLTPDSDL ESVKTLSSDA QHLQNSALPP LSTESEGHHV FKAGTGAWQA KSSSVPTPPP IQLGSLVTQE APAQDSLGSW INSSPDSSEN LSEIPLSHKE RKEILTGTKC IWVKAARRRS RALGTEGRHL LAPATERSSL SLHSLSEGDD ARPPGPLACK RPPSPTLQHA ASEDNLSSST GEAPSRAVGH HGDGPRPWLR GQKKSLGKKR EESLEAKRRK RRSRSFEVTG QGLSHPKTHL LGPHQAERIS DHRMPVCRHP APGIRHLGKV TLPLAKVKLP PSQNTGPGDS SPLAVPPNPG GGSRRATRGP RLPHGTSTHG KDGCSRHN
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