About PWWP domain-containing DNA repair factor 3A
PWWP domain-containing DNA repair factor 3A (PWWP3A) is a protein
from Homo sapiens identified by UniProt accession
Q2TAK8, 710 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | PWWP domain-containing DNA repair factor 3A |
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| UniProt accession | Q2TAK8 |
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| Gene | PWWP3A |
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| Organism | Homo sapiens |
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| Length | 710 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (12)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.08
- vital capacity · score 0.05
- attention deficit hyperactivity disorder · score 0.04
- dehydrated hereditary stomatocytosis · score 0.03
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2 · score 0.03
- schizophrenia 15 · score 0.03
- immunodeficiency 69 · score 0.03
- psoriasis · score 0.00
- Ataxia-telangiectasia · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAK8-F1 | alphafold | PREDICTED | 63.05 | — |
Amino-acid sequence (710 residues)
MADAKYVLCR WEKRLWPAKV LARTATSTKN KRRKEYFLAV QILSLEEKIK VKSTEVEILE KSQIEAIASS LASQNEVPAA PLEELAYRRS LRVALDVLSE GSIWSQESSA GTGRADRSLR GKPMEHVSSP CDSNSSSLPR GDVLGSSRPH RRRPCVQQSL SSSFTCEKDP ECKVDHKKGL RKSENPRGPL VLPAGGGAQD ESGSRIHHKN WTLASKRGGN SAQKASLCLN GSSLSEDDTE RDMGSKGGSW AAPSLPSGVR EDDPCANAEG HDPGLPLGSL TAPPAPEPSA CSEPGECPAK KRPRLDGSQR PPAVQLEPMA AGAAPSPGPG PGPRESVTPR STARLGPPPS HASADATRCL PCPDSQKLEK ECQSSEESMG SNSMRSILEE DEEDEEPPRV LLYHEPRSFE VGMLVWHKHK KYPFWPAVVK SVRQRDKKAS VLYIEGHMNP KMKGFTVSLK SLKHFDCKEK QTLLNQARED FNQDIGWCVS LITDYRVRLG CGSFAGSFLE YYAADISYPV RKSIQQDVLG TKLPQLSKGS PEEPVVGCPL GQRQPCRKML PDRSRAARDR ANQKLVEYIV KAKGAESHLR AILKSRKPSR WLQTFLSSSQ YVTCVETYLE DEGQLDLVVK YLQGVYQEVG AKVLQRTNGD RIRFILDVLL PEAIICAISA VDEVDYKTAE EKYIKGPSLS YREKEIFDNQ LLEERNRRRR
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