About Transcriptional regulator QRICH1
Transcriptional regulator QRICH1 (QRICH1) is a protein
from Homo sapiens identified by UniProt accession
Q2TAL8, 776 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Transcriptional regulator QRICH1 |
|---|
| UniProt accession | Q2TAL8 |
|---|
| Gene | QRICH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 776 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (154)
Diseases linked to this target (Open Targets).
- Ververi-Brady syndrome · score 0.75
- Intellectual disability · score 0.55
- genetic disorder · score 0.52
- syndromic intellectual disability · score 0.37
- Intellectual disability, mild · score 0.34
- neurodegenerative disease · score 0.32
- autism spectrum disorder · score 0.12
- HbA1c measurement · score 0.07
- mean corpuscular hemoglobin · score 0.06
- Heterotaxia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAL8-F1 | alphafold | PREDICTED | 57.48 | — |
Amino-acid sequence (776 residues)
MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT TTMVYQQGGN CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ QVQVQVQVQQ SPQQVSAQLS PQLTVHQPTE QPIQVQVQIQ GQAPQSAAPS IQTPSLQSPS PSQLQAAQIQ VQHVQAAQQI QAAEIPEEHI PHQQIQAQLV AGQSLAGGQQ IQIQTVGALS PPPSQQGSPR EGERRVGTAS VLQPVKKRKV DMPITVSYAI SGQPVATVLA IPQGQQQSYV SLRPDLLTVD SAHLYSATGT ITSPTGETWT IPVYSAQPRG DPQQQSITHI AIPQEAYNAV HVSGSPTALA AVKLEDDKEK MVGTTSVVKN SHEEVVQTLA NSLFPAQFMN GNIHIPVAVQ AVAGTYQNTA QTVHIWDPQQ QPQQQTPQEQ TPPPQQQQQQ LQVTCSAQTV QVAEVEPQSQ PQPSPELLLP NSLKPEEGLE VWKNWAQTKN AELEKDAQNR LAPIGRRQLL RFQEDLISSA VAELNYGLCL MTREARNGEG EPYDPDVLYY IFLCIQKYLF ENGRVDDIFS DLYYVRFTEW LHEVLKDVQP RVTPLGYVLP SHVTEEMLWE CKQLGAHSPS TLLTTLMFFN TKYFLLKTVD QHMKLAFSKV LRQTKKNPSN PKDKSTSIRY LKALGIHQTG QKVTDDMYAE QTENPENPLR CPIKLYDFYL FKCPQSVKGR NDTFYLTPEP VVAPNSPIWY SVQPISREQM GQMLTRILVI REIQEAIAVA NASTMH
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