About Tumor suppressor candidate gene 1 protein
Tumor suppressor candidate gene 1 protein (TUSC1) is a protein
from Homo sapiens identified by UniProt accession
Q2TAM9, 209 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Tumor suppressor candidate gene 1 protein |
|---|
| UniProt accession | Q2TAM9 |
|---|
| Gene | TUSC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- motion sickness · score 0.29
- arterial stiffness measurement · score 0.25
- neurodegenerative disease · score 0.23
- feeling emotionally hurt measurement · score 0.16
- self reported educational attainment · score 0.15
- major depressive disorder · score 0.15
- unipolar depression · score 0.15
- neoplasm · score 0.08
- ejection fraction measurement · score 0.07
- appendicular lean mass · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAM9-F1 | alphafold | PREDICTED | 67.16 | — |
Amino-acid sequence (209 residues)
MWRMRGGATR RGSCCGGDGA ADGRGPGRSG RARGGGSPSG GGGGVGWRGR ADGARQQLEE RFADLAASHL EAIRARDEWD RQNARLRQEN ARLRLENRRL KRENRSLFRQ ALRLPGEGGN GTPAEARRVP EEASTNRRAR DSGREDEPGS PRALRARLEK LEAMYRRALL QLHLEQRGPR PSGDKEEQPL QEPDSGLRSR DSEPSGPWL
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