About Autophagy-related protein 2 homolog A
Autophagy-related protein 2 homolog A (ATG2A) is a protein
from Homo sapiens identified by UniProt accession
Q2TAZ0, 1938 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Autophagy-related protein 2 homolog A |
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| UniProt accession | Q2TAZ0 |
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| Gene | ATG2A |
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| Organism | Homo sapiens |
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| Length | 1938 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- adolescent idiopathic scoliosis · score 0.19
- hair colour measurement · score 0.19
- primary ovarian insufficiency · score 0.12
- genetic disorder · score 0.12
- neutrophil percentage of leukocytes · score 0.04
- hepatocellular carcinoma · score 0.04
- mean corpuscular hemoglobin concentration · score 0.02
- appendicular lean mass · score 0.02
- gout · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TAZ0-F1 | alphafold | PREDICTED | 67.40 | — |
Amino-acid sequence (1938 residues)
MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR DIHLEIWSVN EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG LQLTLQPRRG PAPGAADSQS WASCMTTSLQ LAQECLRDGL PEPSEPPQPL EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH SPGDGERGVA VEVRVQRLEY CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP AQEEPPEPPL QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD PLTNPLLNLD NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR RLSAQAHPAG KMAPNPLLDT MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ RACPCSHVRL TGTAVQLSWE LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL TFPGTLGSQA SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA DLRPEPDPWA GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD LHGIYEDGGK PPVPCLRVSK ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE VAPEKGEELE LSVESPCELR EPEPSPFSSK RTMYETEEMV IPGDPEEMRT FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND LLMWEPADLL PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR LEAVHGELVL DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY PLPSHLDLPS FAPPAQLAPT IYPSEEGVTE RGASGRKGQG RGPHMLSTAV RIHLDPHKNV KEFLVTLRLH KATLRHYMAL PEQSWHSQLL EFLDVLDDPV LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT LSSNIIMDTS TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP SPTEIAGQKL SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP SGGHLPQASP ISVYLFPGER SGAPPPSPPV GGPAGSLGSC SEEKEDEREE EGDGDTLDSD EFCILDAPGL GIPPRDGEPV VTQLHPGPIV VRDGYFSRPI GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP GHRARTGLSG PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP RRAHSNMLTI KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF FTSLVAGINP VVPGETSAEA RPETRAQPSS PLEGQAEGVE TTGSQEAPGG GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH GKHVTMDQVG TFAGLLIGLA QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ LPGLLGGVGP MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG VAKAYDTVRE GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP LILATEATSS LLGGMRNQIV PDAHKDHALK WRSDSAQD
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