About Single-strand DNA endonuclease ASTE1
Single-strand DNA endonuclease ASTE1 (ASTE1) is a protein
from Homo sapiens identified by UniProt accession
Q2TB18, 679 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Single-strand DNA endonuclease ASTE1 |
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| UniProt accession | Q2TB18 |
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| Gene | ASTE1 |
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| Organism | Homo sapiens |
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| Length | 679 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.09
- hip bone mineral density · score 0.06
- hip bone size · score 0.06
- protein measurement · score 0.06
- fat body mass · score 0.05
- smoking behavior · score 0.04
- progressive supranuclear palsy-pure akinesia with gait freezing syndrome · score 0.03
- fibromatosis · score 0.01
- cancer · score 0.01
- cardiomyopathy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TB18-F1 | alphafold | PREDICTED | 85.29 | — |
Amino-acid sequence (679 residues)
MGIRGLMSFV EDHSNEFFTD LKLRDTKIVI DGYALFHRLC FSSNLDLRYG GDYDSFADVV QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI QMAHSLSVGG SGYVCPLLIR EVFIQVLIKL RVCFVQCFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLKT GFCPLNSFQW RNMNTIKGTQ NYIPAKCFSL DAFCHHFSNM NKALLPLFAV LCGNDHVNLP IMETFLSKAR LPLGATSSKG RRHHRILGLL NWLSHFANPT EALDNVLKYL PKKDRENVKE LLCCSMEEYQ QSQVKLQDFF QCGTYVCPDA LNLGLPEWVL VALAKGQLSP FISDALVLRR TILPTQVENM QQPNAHRISQ PIRQIIYGLL LNASPHLDKT SWNALPPQPL AFSEVERINK NIRTSIIDAV ELAKDHSDLS RLTELSLRRR QMLLLETLKV KQTILEPIPT SLKLPIAVSC YWLQHTETKA KLHHLQSLLL TMLVGPLIAI INSPGKEELQ EDGAKMLYAE FQRVKAQTRL GTRLDLDTAH IFCQWQSCLQ MGMYLNQLLS TPLPEPDLTR LYSGSLVHGL CQQLLASTSV ESLLSICPEA KQLYEYLFNA TRSYAPAEIF LPKGRSNSKK KRQKKQNTSC SKNRGRTTAH TKCWYEGNNR FGLLMVENLE EHSEASNIE
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