About Kelch-like protein 40
Kelch-like protein 40 (KLHL40) is a protein
from Homo sapiens identified by UniProt accession
Q2TBA0, 621 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Kelch-like protein 40 |
|---|
| UniProt accession | Q2TBA0 |
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| Gene | KLHL40 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (130)
Diseases linked to this target (Open Targets).
- nemaline myopathy 8 · score 0.84
- severe congenital nemaline myopathy · score 0.37
- genetic disorder · score 0.19
- body fat distribution · score 0.15
- myopathy · score 0.06
- GNE myopathy · score 0.06
- myofibrillar myopathy 3 · score 0.06
- Distal myotilinopathy · score 0.06
- tibial muscular dystrophy · score 0.05
- autosomal recessive limb-girdle muscular dystrophy type 2L · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TBA0-F1 | alphafold | PREDICTED | 89.42 | — |
Amino-acid sequence (621 residues)
MALGLEQAEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVRAG EREFPCHRLV LAACSPYFRA RFLAEPERAG ELHLEEVSPD VVAQVLHYLY TSEIALDEAS VQDLFAAAHR FQIPSIFTIC VSFLQKRLCL SNCLAVFRLG LLLDCARLAV AARDFICAHF TLVARDADFL GLSADELIAI ISSDGLNVEK EEAVFEAVMR WAGSGDAEAQ AERQRALPTV FESVRCRLLP RAFLESRVER HPLVRAQPEL LRKVQMVKDA HEGRITTLRK KKKGKDGAGA KEADKGTSKA KAEEDEEAER ILPGILNDTL RFGMFLQDLI FMISEEGAVA YDPAANECYC ASLSNQVPKN HVSLVTKENQ VFVAGGLFYN EDNKEDPMSA YFLQFDHLDS EWLGMPPLPS PRCLFGLGEA LNSIYVVGGR EIKDGERCLD SVMCYDRLSF KWGESDPLPY VVYGHTVLSH MDLVYVIGGK GSDRKCLNKM CVYDPKKFEW KELAPMQTAR SLFGATVHDG RIIVAAGVTD TGLTSSAEVY SITDNKWAPF EAFPQERSSL SLVSLVGTLY AIGGFATLET ESGELVPTEL NDIWRYNEEE KKWEGVLREI AYAAGATFLP VRLNVLCLTK M
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