Prickle-like protein 4 (PRICKLE4)

About Prickle-like protein 4

Prickle-like protein 4 (PRICKLE4) is a protein from Homo sapiens identified by UniProt accession Q2TBC4, 344 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Prickle-like protein 4
UniProt accession	Q2TBC4
Gene	PRICKLE4
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.19
mean corpuscular hemoglobin concentration · score 0.13
mean corpuscular hemoglobin · score 0.07
body mass index · score 0.06
mean reticulocyte volume · score 0.05
lean body mass · score 0.05
platelet component distribution width · score 0.04
whole body water mass · score 0.04
smoking status measurement · score 0.04
hyperinsulinism due to INSR deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2TBC4-F1	alphafold	PREDICTED	68.39	—

Amino-acid sequence (344 residues)

MSPQGPAVLS LGSLCLDTNQ APNWTGLQTL LQQLPPQDID ERYCLALGEE ERAELQLFCA RRKQEALGQG VARLVLPKLE GHTCEKCREL LKPGEYGVFA ARAGEQRCWH QPCFACQACG QALINLIYFY HDGQLYCGRH HAELLRPRCP ACDQLIFSWR CTEAEGQRWH ENHFCCQDCA GPLGGGRYAL PGGSPCCPSC FENRYSDAGS SWAGALEGQA FLGETGLDRT EGRDQTSVNS ATLSRTLLAA AGGSSLQTQR GLPGSSPQQE NRPGDKAEAP KGQEQCRLET IRDPKDTPFS TCSSSSDSEP EGFFLGERLP QSWKTPGSLQ AEDSNASKTH CTMC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards