About CWF19-like protein 2
CWF19-like protein 2 (CWF19L2) is a protein
from Homo sapiens identified by UniProt accession
Q2TBE0, 894 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | CWF19-like protein 2 |
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| UniProt accession | Q2TBE0 |
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| Gene | CWF19L2 |
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| Organism | Homo sapiens |
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| Length | 894 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.39
- pulse pressure measurement · score 0.39
- Agents acting on the renin-angiotensin system use measurement · score 0.26
- self reported educational attainment · score 0.26
- Diuretic use measurement · score 0.22
- Beta blocking agent use measurement · score 0.22
- hypertension · score 0.22
- diastolic blood pressure · score 0.21
- cardiovascular disease · score 0.19
- blood pressure · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2TBE0-F1 | alphafold | PREDICTED | 66.30 | — |
Amino-acid sequence (894 residues)
MATSMAAASG RFESAKSIEE RKEQTRNARA EVLRQAKANF EKEERRKELK RLRGEDTWML PDVNERIEQF SQEHSVKKKK KKDKHSKKAK KEKKKKSKKQ KYEKNNESSD SSSSSEDEWV EAVPSQTPDK EKAWKVKDEK SGKDDTQIIK RDEWMTVDFM SVKTVSSSSL KAEKETMRKI EQEKNQALEQ SKLMERELNP YWKDGGTGLP PEDCSVSSIT KVSVVEDGGL SWLRKSYLRM KEQAEKQSRN FEDIVAERYG SMEIFQSKLE DAEKAASTKE DYRRERWRKP TYSDKAQNCQ ESRESDLVKY GNSSRDRYAT TDTAKNSNNE KFIGDEKDKR PGSLETCRRE SNPRQNQEFS FGNLRAKFLR PSDDEELSFH SKGRKFEPLS SSSALVAQGS LCSGFRKPTK NSEERLTSWS RSDGRGDKKH SNQKPSETST DEHQHVPEDP REKSQDEVLR DDPPKKEHLR DTKSTFAGSP ERESIHILSV DEKNKLGAKI IKAEMMGNME LAEQLKVQLE KANKFKETIT QIPKKSGVEN EDQQEVILVR TDQSGRVWPV NTPGKSLESQ GGRRKRQMVS THEERERVRY FHDDDNLSLN DLVKNEKMGT AENQNKLFMR MASKFMGKTD GDYYTLDDMF VSKAAERERL GEEEENQRKK AIAEHRSLAA QMEKCLYCFD SSQFPKHLIV AIGVKVYLCL PNVRSLTEGH CLIVPLQHHR AATLLDEDIW EEIQMFRKSL VKMFEDKGLD CIFLETNMSM KKQYHMVYEC IPLPKEVGDM APIYFKKAIM ESDEEWSMNK KLIDLSSKDI RKSVPRGLPY FSVDFGLHGG FAHVIEDQHK FPHYFGKEII GGMLDIEPRL WRKGIRESFE DQRKKALQFA QWWKPYDFTK SKNY
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