Sialate:O-sulfotransferase 2 (WSCD2)

About Sialate:O-sulfotransferase 2

Sialate:O-sulfotransferase 2 (WSCD2) is a protein from Homo sapiens identified by UniProt accession Q2TBF2, 565 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Sialate:O-sulfotransferase 2
UniProt accession	Q2TBF2
Gene	WSCD2
Organism	Homo sapiens
Length	565 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.50
body fat percentage · score 0.49
BMI-adjusted waist-hip ratio · score 0.48
appendicular lean mass · score 0.47
waist-hip ratio · score 0.46
schizophrenia · score 0.45
BMI-adjusted waist circumference · score 0.42
risk-taking behaviour · score 0.39
vital capacity · score 0.37
body mass index · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2TBF2-F1	alphafold	PREDICTED	78.56	—

Amino-acid sequence (565 residues)

MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN PYKALMAEFN RKYGGHIGFA AHAHWKGKEW PEFVRNYAPW WATHTLDWLK FGKKVLVVHF EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS AYIKMVDAAL KGRNLTGVPD DYYPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards