FH1/FH2 domain-containing protein 3 (FHOD3)

About FH1/FH2 domain-containing protein 3

FH1/FH2 domain-containing protein 3 (FHOD3) is a protein from Homo sapiens identified by UniProt accession Q2V2M9, 1422 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	FH1/FH2 domain-containing protein 3
UniProt accession	Q2V2M9
Gene	FHOD3
Organism	Homo sapiens
Length	1422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.61
electrocardiography · score 0.40
heel bone mineral density · score 0.34
adolescent idiopathic scoliosis · score 0.33
gut microbiome measurement · score 0.32
diet measurement · score 0.31
pulse pressure measurement · score 0.28
systolic blood pressure · score 0.28
bone quantitative ultrasound measurement · score 0.25
heart rate · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2V2M9-F1	alphafold	PREDICTED	63.56	—

Amino-acid sequence (1422 residues)

MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL QAPHKLDDCT LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD GMNGVINRNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG GGEHRGLDRR RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKY SNFGNNSYHS SRPSSGSSVP TTPTSSVSPP QEARLERSSP SGLLTSSFRQ HQESLAAERE RRRQEREERL QRIEREERNK FRYKYLEQLA AEEHEKELRS RSVSRGRADL SLDLTSPAAP ACLAPLSHSP SSSDSQEALT VSASSPGTPH HPQASAGDPE PESEAEPEAE AGAGQVADEA GQDIASAHEG AETEVEQALE QEPEERASLS EKERQNEGVN ERDNCSASSV SSSSSTLERE EKEDKLSRDR TTGLWPAGVQ DAGVNGQCGD ILTNKRFMLD MLYAHNRKSP DDEEKGDGEA GRTQQEAEAV ASLATRISTL QANSQTQDES VRRVDVGCLD NRGSVKAFAE KFNSGDLGRG SISPDAEPND KVPETAPVQP KTESDYIWDQ LMANPRELRI QDMDFTDLGE EDDIDVLDVD LGHREAPGPP PPPPPTFLGL PPPPPPPLLD SIPPPPVPGN LLVPPPPVFN APQGLGWSQV PRGQPTFTKK KKTIRLFWNE VRPFDWPCKN NRRCREFLWS KLEPIKVDTS RLEHLFESKS KELSVSKKTA ADGKRQEIIV LDSKRSNAIN IGLTVLPPPR TIKIAILNFD EYALNKEGIE KILTMIPTDE EKQKIQEAQL ANPEIPLGSA EQFLLTLSSI SELSARLHLW AFKMDYETTE KEVAEPLLDL KEGIDQLENN KTLGFILSTL LAIGNFLNGT NAKAFELSYL EKVPEVKDTV HKQSLLHHVC TMVVENFPDS SDLYSEIGAI TRSAKVDFDQ LQDNLCQMER RCKASWDHLK AIAKHEMKPV LKQRMSEFLK DCAERIIILK IVHRRIINRF HSFLLFMGHP PYAIREVNIN KFCRIISEFA LEYRTTRERV LQQKQKRANH RERNKTRGKM ITDSGKFSGS SPAPPSQPQG LSYAEDAAEH ENMKAVLKTS SPSVEDATPA LGVRTRSRAS RGSTSSWTMG TDDSPNVTDD AADEIMDRIV KSATQVPSQR VVPRERKRSR ANRKSLRRTL KSGLTPEEAR ALGLVGTSEL QL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards