About Chromosome-associated kinesin KIF4B
Chromosome-associated kinesin KIF4B (KIF4B) is a protein
from Homo sapiens identified by UniProt accession
Q2VIQ3, 1234 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Chromosome-associated kinesin KIF4B |
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| UniProt accession | Q2VIQ3 |
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| Gene | KIF4B |
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| Organism | Homo sapiens |
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| Length | 1234 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.39
- mean corpuscular hemoglobin concentration · score 0.36
- PHF-tau measurement · score 0.30
- mean corpuscular volume · score 0.27
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.21
- vitamin D measurement · score 0.20
- ovarian cancer · score 0.18
- thyroid gland adenocarcinoma · score 0.18
- esophageal cancer · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2VIQ3-F1 | alphafold | PREDICTED | 71.48 | — |
Amino-acid sequence (1234 residues)
MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGETQ VVVGTDKSFT YDFVFDPCTE QEEVFNKAVA PLIKGIFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGIIPRVIQ LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISI EQRKKSDKNC SFRSKLHLVD LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGSFVPYRD SKLTRLLQDS LGGNSHTLMI ACVSPADSNL EETLSTLRYA DRARKIKNKP IVNIDPHTAE LNHLKQQVQQ LQVLLLQAHG GTLPGSINAE PSENLQSLME KNQSLVEENE KLSRCLSKAA GQTAQMLERI ILTEQVNEKL NAKLEELRQH VACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET VACTAAAIDT AVEEEAQVET SPETSRSSDA FTTQHALHQA QMSKEVVELN NALALKEALV RKMTQNDNQL QPIQFQYQDN IKNLELEVIN LQKEKEELVR ELQTAKKNVN QAKLSEHRHK LLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI WMMKNQRVQL MRQMKEDAEK FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSSVL RRKTEEAAAA NKRLKDALQK QREVTDKRKE TQSHGKEGIA ARVRNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVVQ LKEKKESREN PPPKLRKCTF SLSEVHGQVL ESEDCITKQI ESLETEMELR SAQIADLQQK LLDAESEDRP KQCWENIATI LEAKCALKYL IGELVSSKIH VTKLENSLRQ SKASCADMQK MLFEEQNHFS EIETELQAEL VRMEQQHQEK VLYLVSQLQE SQMAEKQLEK SASEKEQQLV STLQCQDEEL EKMREVCEQN QQLLQENEII KQKLILLQVA SRQKHLPNDT LLSPDSSFEY IPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DGDSDEGDDE EWKPTKLVKV SRKNIQGCSC KGWCGNKQCG CRKQKSDCGV DCSCDPTKCR NRQQGKDSLG TVEQTQDSEG SFKLEDPTEV TPGLSFFNPV CATPNSKILK EMCDMEQVLS KKTAPAPSPF DLPESKHGAT EYQQNKPPGK KKKRALASNT SFFSGCSPIE EEAH
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