About Eukaryotic translation initiation factor 2 subunit 3B
Eukaryotic translation initiation factor 2 subunit 3B (EIF2S3B) is a protein
from Homo sapiens identified by UniProt accession
Q2VIR3, 472 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 2 subunit 3B |
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| UniProt accession | Q2VIR3 |
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| Gene | EIF2S3B |
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| Organism | Homo sapiens |
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| Length | 472 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (10)
Diseases linked to this target (Open Targets).
- dentures · score 0.23
- dental caries · score 0.18
- mean reticulocyte volume · score 0.02
- mean corpuscular hemoglobin concentration · score 0.02
- monocyte count · score 0.02
- mean corpuscular volume · score 0.02
- erythrocyte count · score 0.02
- neoplasm · score 0.01
- cancer · score 0.01
- type 1 diabetes mellitus · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2VIR3-F1 | alphafold | PREDICTED | 85.14 | — |
Amino-acid sequence (472 residues)
MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA ISGVHTVRFK NELERNITIK LGYANAKIYQ LDDPSCPRPE CYRSCGSSMP DEFPTDIPGT KGNFRLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM KLKHILILQN KIDLVKERQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQETEVRPGI VSKDSEGKLM CKSIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQILGA VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD
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