About Cytoplasmic tRNA 2-thiolation protein 2
Cytoplasmic tRNA 2-thiolation protein 2 (CTU2) is a protein
from Homo sapiens identified by UniProt accession
Q2VPK5, 515 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Cytoplasmic tRNA 2-thiolation protein 2 |
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| UniProt accession | Q2VPK5 |
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| Gene | CTU2 |
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| Organism | Homo sapiens |
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| Length | 515 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome · score 0.76
- heel bone mineral density · score 0.26
- congenital anomaly of kidney and urinary tract · score 0.26
- congenital hydronephrosis · score 0.26
- monocyte count · score 0.24
- hemoglobin measurement · score 0.21
- body height · score 0.21
- HbA1c measurement · score 0.21
- Seizure · score 0.18
- reticulocyte count · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2VPK5-F1 | alphafold | PREDICTED | 79.36 | — |
Amino-acid sequence (515 residues)
MCQVGEDYGE PAPEEPPPAP RPSREQKCVK CKEAQPVVVI RAGDAFCRDC FKAFYVHKFR AMLGKNRLIF PGEKVLLAWS GGPSSSSMVW QVLEGLSQDS AKRLRFVAGV IFVDEGAACG QSLEERSKTL AEVKPILQAT GFPWHVVALE EVFSLPPSVL WCSAQELVGS EGAYKAAVDS FLQQQHVLGA GGGPGPTQGE EQPPQPPLDP QNLARPPAPA QTEALSQLFC SVRTLTAKEE LLQTLRTHLI LHMARAHGYS KVMTGDSCTR LAIKLMTNLA LGRGAFLAWD TGFSDERHGD VVVVRPMRDH TLKEVAFYNR LFSVPSVFTP AVDTKAPEKA SIHRLMEAFI LRLQTQFPST VSTVYRTSEK LVKGPRDGPA AGDSGPRCLL CMCALDVDAA DSATAFGAQT SSRLSQMQSP IPLTETRTPP GPCCSPGVGW AQRCGQGACR REDPQACIEE QLCYSCRVNM KDLPSLDPLP PYILAEAQLR TQRAWGLQEI RDCLIEDSDD EAGQS
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