About UV-stimulated scaffold protein A
UV-stimulated scaffold protein A (UVSSA) is a protein
from Homo sapiens identified by UniProt accession
Q2YD98, 709 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | UV-stimulated scaffold protein A |
|---|
| UniProt accession | Q2YD98 |
|---|
| Gene | UVSSA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 709 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- UV-sensitive syndrome · score 0.70
- neurodegenerative disease · score 0.40
- body height · score 0.32
- sunburn · score 0.30
- lean body mass · score 0.27
- appendicular lean mass · score 0.27
- neurofibrillary tangles measurement · score 0.25
- fat body mass · score 0.23
- vital capacity · score 0.20
- base metabolic rate measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2YD98-F1 | alphafold | PREDICTED | 73.57 | — |
Amino-acid sequence (709 residues)
MDQKLSKLVE ELTTSGEPRL NPEKMKELKK ICKSSEEQLS RAYRLLIAQL TQEHAEIRLS AFQIVEELFV RSHQFRMLVV SNFQEFLELT LGTDPAQPLP PPREAAQRLR QATTRAVEGW NEKFGEAYKK LALGYHFLRH NKKVDFQDTN ARSLAERKRE EEKQKHLDKI YQERASQAER EMQEMSGEIE SCLTEVESCF RLLVPFDFDP NPETESLGMA SGMSDALRSS CAGQVGPCRS GTPDPRDGEQ PCCSRDLPAS AGHPRAGGGA QPSQTATGDP SDEDEDSDLE EFVRSHGLGS HKYTLDVELC SEGLKVQENE DNLALIHAAR DTLKLIRNKF LPAVCSWIQR FTRVGTHGGC LKRAIDLKAE LELVLRKYKE LDIEPEGGER RRTEALGDAE EDEDDEDFVE VPEKEGYEPH IPDHLRPEYG LEAAPEKDTV VRCLRTRTRM DEEVSDPTSA AAQLRQLRDH LPPPSSASPS RALPEPQEAQ KLAAERARAP VVPYGVDLHY WGQELPTAGK IVKSDSQHRF WKPSEVEEEV VNADISEMLR SRHITFAGKF EPVQHWCRAP RPDGRLCERQ DRLKCPFHGK IVPRDDEGRP LDPEDRAREQ RRQLQKQERP EWQDPELMRD VEAATGQDLG SSRYSGKGRG KKRRYPSLTN LKAQADTARA RIGRKVFAKA AVRRVVAAMN RMDQKKHEKF SNQFNYALN
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