About Hereditary hemochromatosis protein
Hereditary hemochromatosis protein (HFE) is a protein
from Homo sapiens identified by UniProt accession
Q30201, 348 residues long.
MolForge cross-references it against 0 known binders and
413 disease associations.
Target properties
| Protein name | Hereditary hemochromatosis protein |
|---|
| UniProt accession | Q30201 |
|---|
| Gene | HFE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 348 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (413)
Diseases linked to this target (Open Targets).
- hereditary hemochromatosis type 1 · score 0.79
- Familial porphyria cutanea tarda · score 0.63
- variegate porphyria · score 0.60
- diabetic retinopathy · score 0.59
- Alzheimer disease type 1 · score 0.58
- hemochromatosis · score 0.57
- hereditary hemochromatosis · score 0.57
- mean corpuscular volume · score 0.47
- mean corpuscular hemoglobin concentration · score 0.45
- cardiomyopathy · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q30201-F1 | alphafold | PREDICTED | 88.09 | — |
Amino-acid sequence (348 residues)
MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE
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