Defensin beta 136 (DEFB136)

About Defensin beta 136

Defensin beta 136 (DEFB136) is a protein from Homo sapiens identified by UniProt accession Q30KP8, 78 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Defensin beta 136
UniProt accession	Q30KP8
Gene	DEFB136
Organism	Homo sapiens
Length	78 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.31
forced expiratory volume · score 0.26
risky sexual behaviour measurement · score 0.25
lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
monocyte count · score 0.23
triglyceride measurement · score 0.23
Thyroid preparation use measurement · score 0.22
FEV/FVC ratio · score 0.22
neurodegenerative disease · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q30KP8-F1	alphafold	PREDICTED	81.92	—

Amino-acid sequence (78 residues)

MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC CKNMTRFQPP QAKDPWVH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards