Beta-defensin 135 (DEFB135)

About Beta-defensin 135

Beta-defensin 135 (DEFB135) is a protein from Homo sapiens identified by UniProt accession Q30KP9, 77 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Beta-defensin 135
UniProt accession	Q30KP9
Gene	DEFB135
Organism	Homo sapiens
Length	77 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
cutaneous melanoma · score 0.23
glioblastoma multiforme · score 0.20
electrocardiography · score 0.18
hypothyroidism · score 0.17
monocyte count · score 0.13
dilated cardiomyopathy · score 0.13
triglyceride measurement · score 0.12
cholelithiasis · score 0.12
C-reactive protein measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q30KP9-F1	alphafold	PREDICTED	85.72	—

Amino-acid sequence (77 residues)

MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK NEQYRILCDT IHLCCVNPKY LPILTGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards