About Anoctamin-4
Anoctamin-4 (ANO4) is a protein
from Homo sapiens identified by UniProt accession
Q32M45, 955 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Anoctamin-4 |
|---|
| UniProt accession | Q32M45 |
|---|
| Gene | ANO4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 955 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.50
- COVID-19 · score 0.37
- generalized epilepsy with febrile seizures plus · score 0.34
- attention deficit hyperactivity disorder · score 0.29
- antisocial behaviour measurement · score 0.28
- substance abuse · score 0.28
- temporal lobe epilepsy · score 0.26
- PHF-tau measurement · score 0.24
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q32M45-F1 | alphafold | PREDICTED | 78.89 | — |
Amino-acid sequence (955 residues)
MEASSSGITN GKTKVFHPEG GVDLQGYQLD MQILPDGPKS DVDFSEILNA IQEMAKDVNI LFDELEAVSS PCKDDDSLLH PGNLTSTSDD ASRLEAGGET VPERNKSNGL YFRDGKCRID YILVYRKSNP QTEKREVFER NIRAEGLQME KESSLINSDI IFVKLHAPWE VLGRYAEQMN VRMPFRRKIY YLPRRYKFMS RIDKQISRFR RWLPKKPMRL DKETLPDLEE NDCYTAPFSQ QRIHHFIIHN KETFFNNATR SRIVHHILQR IKYEEGKNKI GLNRLLTNGS YEAAFPLHEG SYRSKNSIRT HGAENHRHLL YECWASWGVW YKYQPLDLVR RYFGEKIGLY FAWLGWYTGM LFPAAFIGLF VFLYGVTTLD HSQVSKEVCQ ATDIIMCPVC DKYCPFMRLS DSCVYAKVTH LFDNGATVFF AVFMAVWATV FLEFWKRRRA VIAYDWDLID WEEEEEEIRP QFEAKYSKKE RMNPISGKPE PYQAFTDKCS RLIVSASGIF FMICVVIAAV FGIVIYRVVT VSTFAAFKWA LIRNNSQVAT TGTAVCINFC IIMLLNVLYE KVALLLTNLE QPRTESEWEN SFTLKMFLFQ FVNLNSSTFY IAFFLGRFTG HPGAYLRLIN RWRLEECHPS GCLIDLCMQM GIIMVLKQTW NNFMELGYPL IQNWWTRRKV RQEHGPERKI SFPQWEKDYN LQPMNAYGLF DEYLEMILQF GFTTIFVAAF PLAPLLALLN NIIEIRLDAY KFVTQWRRPL ASRAKDIGIW YGILEGIGIL SVITNAFVIA ITSDFIPRLV YAYKYGPCAG QGEAGQKCMV GYVNASLSVF RISDFENRSE PESDGSEFSG TPLKYCRYRD YRDPPHSLVP YGYTLQFWHV LAARLAFIIV FEHLVFCIKH LISYLIPDLP KDLRDRMRRE KYLIQEMMYE AELERLQKER KERKKNGKAH HNEWP
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