About Myosin light chain kinase 3
Myosin light chain kinase 3 (MYLK3) is a protein
from Homo sapiens identified by UniProt accession
Q32MK0, 819 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | Myosin light chain kinase 3 |
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| UniProt accession | Q32MK0 |
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| Gene | MYLK3 |
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| Organism | Homo sapiens |
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| Length | 819 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (172)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy · score 0.43
- Dilated cardiomyopathy · score 0.42
- age at menopause · score 0.18
- mean corpuscular volume · score 0.11
- mean corpuscular hemoglobin · score 0.10
- hypertrophic cardiomyopathy · score 0.08
- left ventricular noncompaction · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
- dilated cardiomyopathy 1AA · score 0.06
- familial atrial fibrillation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q32MK0-F1 | alphafold | PREDICTED | 61.71 | — |
Amino-acid sequence (819 residues)
MSGTSKESLG HGGLPGLGKT CLTTMDTKLN MLNEKVDQLL HFQEDVTEKL QSMCRDMGHL ERGLHRLEAS RAPGPGGADG VPHIDTQAGW PEVLELVRAM QQDAAQHGAR LEALFRMVAA VDRAIALVGA TFQKSKVADF LMQGRVPWRR GSPGDSPEEN KERVEEEGGK PKHVLSTSGV QSDAREPGEE SQKADVLEGT AERLPPIRAS GLGADPAQAV VSPGQGDGVP GPAQAFPGHL PLPTKVEAKA PETPSENLRT GLELAPAPGR VNVVSPSLEV APGAGQGASS SRPDPEPLEE GTRLTPGPGP QCPGPPGLPA QARATHSGGE TPPRISIHIQ EMDTPGEMLM TGRGSLGPTL TTEAPAAAQP GKQGPPGTGR CLQAPGTEPG EQTPEGAREL SPLQESSSPG GVKAEEEQRA GAEPGTRPSL ARSDDNDHEV GALGLQQGKS PGAGNPEPEQ DCAARAPVRA EAVRRMPPGA EAGSVVLDDS PAPPAPFEHR VVSVKETSIS AGYEVCQHEV LGGGRFGQVH RCTEKSTGLP LAAKIIKVKS AKDREDVKNE INIMNQLSHV NLIQLYDAFE SKHSCTLVME YVDGGELFDR ITDEKYHLTE LDVVLFTRQI CEGVHYLHQH YILHLDLKPE NILCVNQTGH QIKIIDFGLA RRYKPREKLK VNFGTPEFLA PEVVNYEFVS FPTDMWSVGV ITYMLLSGLS PFLGETDAET MNFIVNCSWD FDADTFEGLS EEAKDFVSRL LVKEKSCRMS ATQCLKHEWL NNLPAKASRS KTRLKSQLLL QKYIAQRKWK KHFYVVTAAN RLRKFPTSP
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