About CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (PGS1) is a protein
from Homo sapiens identified by UniProt accession
Q32NB8, 556 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial |
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| UniProt accession | Q32NB8 |
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| Gene | PGS1 |
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| Organism | Homo sapiens |
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| Length | 556 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.38
- triglyceride measurement · score 0.37
- Red cell distribution width · score 0.35
- C-reactive protein measurement · score 0.35
- low density lipoprotein cholesterol measurement · score 0.34
- total cholesterol measurement · score 0.34
- apolipoprotein A 1 measurement · score 0.33
- heel bone mineral density · score 0.33
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular volume · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q32NB8-F1 | alphafold | PREDICTED | 85.15 | — |
Amino-acid sequence (556 residues)
MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP WLLLAPLLSP AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL SSPAEFFELM KGQIRVAKRR VVMASLYLGT GPLEQELVDC LESTLEKSLQ AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL PLLRRFPEQV RVSLFHTPHL RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS YFTNRQDRYV FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRAEYC KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW IYPLIQMKPF EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL GTRAEYQILL ASPEVNGFFG AKGVAGAIPA AYVHIERQFF SEVCSLGQQE RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA QIAIVTENQA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ VKLWVKMVTP LIKNFF
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