About tRNA (guanine(37)-N(1))-methyltransferase
tRNA (guanine(37)-N(1))-methyltransferase (TRMT5) is a protein
from Homo sapiens identified by UniProt accession
Q32P41, 509 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | tRNA (guanine(37)-N(1))-methyltransferase |
|---|
| UniProt accession | Q32P41 |
|---|
| Gene | TRMT5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 509 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- Combined oxidative phosphorylation defect type 26 · score 0.73
- neurodegenerative disease · score 0.50
- mitochondrial disease · score 0.37
- genetic disorder · score 0.19
- cortical surface area measurement · score 0.10
- lip morphology measurement · score 0.06
- optic cup area measurement · score 0.03
- type 2 diabetes mellitus · score 0.03
- vital capacity · score 0.03
- Stroke · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q32P41-F1 | alphafold | PREDICTED | 80.72 | — |
Amino-acid sequence (509 residues)
MVLWILWRPF GFSGRFLKLE SHSITESKSL IPVAWTSLTQ MLLEAPGIFL LGQRKRFSTM PETETHERET ELFSPPSDVR GMTKLDRTAF KKTVNIPVLK VRKEIVSKLM RSLKRAALQR PGIRRVIEDP EDKESRLIML DPYKIFTHDS FEKAELSVLE QLNVSPQISK YNLELTYEHF KSEEILRAVL PEGQDVTSGF SRIGHIAHLN LRDHQLPFKH LIGQVMIDKN PGITSAVNKI NNIDNMYRNF QMEVLSGEQN MMTKVRENNY TYEFDFSKVY WNPRLSTEHS RITELLKPGD VLFDVFAGVG PFAIPVAKKN CTVFANDLNP ESHKWLLYNC KLNKVDQKVK VFNLDGKDFL QGPVKEELMQ LLGLSKERKP SVHVVMNLPA KAIEFLSAFK WLLDGQPCSS EFLPIVHCYS FSKDANPAED VRQRAGAVLG ISLEACSSVH LVRNVAPNKE MLCITFQIPA SVLYKNQTRN PENHEDPPLK RQRTAEAFSD EKTQIVSNT
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