DNA-directed RNA polymerase I subunit RPA43 (POLR1F)

About DNA-directed RNA polymerase I subunit RPA43

DNA-directed RNA polymerase I subunit RPA43 (POLR1F) is a protein from Homo sapiens identified by UniProt accession Q3B726, 338 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase I subunit RPA43
UniProt accession	Q3B726
Gene	POLR1F
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

body height · score 0.37
neuroimaging measurement · score 0.35
cortical surface area measurement · score 0.35
brain measurement · score 0.33
cortical thickness · score 0.32
brain volume measurement · score 0.29
cup-to-disc ratio measurement · score 0.29
BMI-adjusted waist circumference · score 0.29
heel bone mineral density · score 0.28
brain aneurysm · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3B726-F1	alphafold	PREDICTED	68.19	—

Amino-acid sequence (338 residues)

MAAGCSEAPR PAAASDGSLV GQAGVLPCLE LPTYAAACAL VNSRYSCLVA GPHQRHIALS PRYLNRKRTG IREQLDAELL RYSESLLGVP IAYDNIKVVG ELGDIYDDQG HIHLNIEADF VIFCPEPGQK LMGIVNKVSS SHIGCLVHGC FNASIPKPEQ LSAEQWQTME INMGDELEFE VFRLDSDAAG VFCIRGKLNI TSLQFKRSEV SEEVTENGTE EAAKKPKKKK KKKDPETYEV DSGTTKLADD ADDTPMEESA LQNTNNANGI WEEEPKKKKK KKKHQEVQDQ DPVFQGSDSS GYQSDHKKKK KKRKHSEEAE FTPPLKCSPK RKGKSNFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards